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Research Chemicals Today

I’ve been involved in the research chemical scene for a long time now and over the years I’ve ingested many, many substances to extrapolate their effects. This is all research to figure out the Structure Activity Relationships (SAR) between different compounds. Basically what compounds hit which receptors and what happens after that. On my journey I’ve been as far as one can go in terms of “highness”!

However the research chemical scene today is dwindling. It’s still producing many novel compounds to bypass laws but only in the most popular areas, which seem to be the empathogens, stimulants and cannabinoids. We have 5-EAPB, a-PVP, MPA and numerous cannabinoids which seem to pop up faster than you can even fully understand the last. My favourites of the cannabinoids have to be the cannabinoid re-uptake inhibitors such as LY-2183240. These compounds don’t actually agonise your cannabinoid receptors as Cannabis and other cannabinoids do but they enhance your own endogenous cannabinoids, so essentially you’re getting high off your own juices! Then when these are combined with agonists such as THC or other synthetic cannabinoids, they enhance the high to such an extent that a gram of weed could last you a week with say 20mg of the CRI’s! Now that is innovation.

I’m not here to talk to you about cannabinoids though. What is really on my agenda is the lack of innovation in the psychedelic realm. PIHKAL and TIHKAL have offered us hundreds of compounds that could be made yet only the most basic are marketed. Now to me this is a problem. I love novel psychedelics. In fact I could name a few that I made up here and now (i.e. 2C-MAL, 4-Bromo-Mescaline, 4-PropO-PiPT etc.).

The fact of the matter is that no-one is producing novel psychedelics anymore. There have been a few in the last couple of years that were great such as 3C-E and bk-2C-B but apart from those (rather meagre) psychedelics, there has been no big bangs, which is what I love. The compounds that could be a big hit are: 5-TOET, ALEPH & ALEPH-2, 2C-EF, 2C-TFM, CPM, 2C-T-21, DMMDA, psi-DOx (these have lowered duration for those who aren’t fans of long psychedelics), MEM, MMDA-2, MMDA-3a (and it’s methyl analogue), MMDA itself (capable of producing ‘brain movies’) and a whole host of other analogues for instance 2C-C-FLY.

I have to give praise to some that are producing such compounds though as DON, DOET, LSZ, AL-LAD and 2C-B-FLY have made it onto the scene recently.

However my main message in this is that as darknets are expanding, the need for analogues and research chemicals has become redundant. People would rather get a gram of MDMA than a gram of MDE or DMMDA. They’d rather get some 2C-B than some 2C-T-16 or 2C-YN. The research chemical scene used to be thriving and everyone wanted to make their mark on the world. Just look at how well MXE has done, and this is not even close to what could be. With a little imagination and drive, even better compounds could be created. They also need to be distributed at the retail end as there are many wholesalers who do produce fantastic products but customers are so dead set on what they know and want there is no room for expansion.

If we are to evolve chemically we must start to abandon the basic drugs we know and love. It’s a risky venture, of course, but those who use drugs engage in risky behaviour all the time, why not expand those boundaries to let in some of the fantastic compounds that are out there waiting to be synthesized? This is evolution at it’s most basic definition and with the introduction of Black Marketplaces it seems we are at a lull, we are not striving to the future but perhaps, someday, we’ll wake up and realise that the compounds many have neglected are the ones that they want the most.

I’ll leave you with this link: http://www.bluelight.org/vb/threads/95736-5-Methyl-MDA-First-time-Craaaaaaazzzy

I should mention the compound in question was not 5-Methyl-MDA but I think it could have been MMDA-3a with a methyl group instead of a methoxy. Basically they got the wrong side and 5-MMDA turned out to be quite poor. However if some bright spark should put that methyl on the top of the molecule then we’ll probably see something similar to this compound.

So do some research, have a read of PIHKAL and TIHKAL, find some compounds that look fun and exciting, and post your interest in the appropriate place (Darknet Marketplace forums, RC companies’ ‘contact us’ page, bluelight and other drug forums, reddit, 420Chan, basically anywhere that has a common interest in these compounds).

Let’s get that Psychedelic RC Train going again!

– Lines of Thought


  1. I just got into research chemicals and I’ve been purchasing them safely with bitcoins. The bites called bitchems. I love 5-apb and 4-fa and mephedrone mostly

  2. I’ve tried some RCs (both stimulants and psychedelics) and I must say that I don’t feel the need to explore them further when I got some really satisfying tools at hand with common substances like Acid, (natural) Mescaline, Dextroamphetamine, R/S Ketamine, pure Cocaine ect.

    These substances are more than enough for my needs, and they have a decent history of human consumption (I know the dangers, so to say)

    I am sure you can get some nice experiences out of experimenting with RCs, but tbh I have other things to do in my life than experimenting with drugs every second day or so…

  3. Why would you opt for MDE over MDMA or MDA ? The latter 2 are tried and true for over 3 decades. The effects are well studied and understood.
    As for psycadelic RCs, I couldn’t disagree more. That is because I associate Entheogens with spirituality / religion as opposed to party drugs. Much of the fulfilling process involves the gathering and preperation of the natural components. When you tweak the natural alkaloids in a lab it loses something.
    Regarding all other RCs – well go ahead and be a guinea pig. After time has passed, and the research comes in, then I will be able to make a more informed decision about trying it. One that will likely come at your expense or anyone else willing to put unknown substances in their bodies.

    • RC Tryptamines are a wonderful thing to explore. And I have never come across any talk of negative side effects from ingestion of ANY tryptamines, even those with minimal recorded history.

      4-HO-MET for example is basically a much more easy going much more visual magic mushroom trip. Psilocin (active ingredient in mushrooms) is 4-HO-DMT. And just a cool note that the same naming scheme that gives us psilocin makes 4-HO-MET be called metocin, pronounced like medicine! Love it. Hah.

      Another RC tryptamine that is well worth the time and definitely is safe is 4-AcO-DMT. This is a pro-drug of psilocin, and by itself is too large to pass the blood brain barrier. This means it causes no psychological effect until your body metabolizes it into a smaller molecule, and what does it metabolize into? Well first pass metabolism changes all the ingested 4-AcO-DMT into good ol’ trustworthy 4-HO-DMT / psilocin. With a barely perceivable increase in come up time. Thousands of years of historical anecdotes and tests showing it safe to ingest. AND, if caught with it in your possession, unlike psilocin itself, 4-AcO-DMT is not technically illegal. A rather annoyed police officer would have no choice but to give it back to you. I love being able to bring some on a trip even if I’m not sure I will even want to use it, because it isn’t the slightest bit risky to do so.

      This is a major reason why we should keep synthesizing and trying new analogues. MXE for example… is just a wonderful thing. No other NMDA antagonist has an effect quite like it, so you cannot substitute that high with ketamine or DXM or PCP or anything of the sort. 4-HO-MET is so very nice to have around when I don’t feel like going through the difficulty of a strong mushroom trip. Sometimes I just want a very pretty, more easy going but still bloody intense trip. I always describe them to people as 4-HO-DMT (magic mushrooms) are like a wizened old teacher scolding you and making you uncomfortable and guilty and nauseous. 4-HO-MET is more akin to a playful preteen girl who just wants to play around and have some fun and spend a while fantasizing together. And as I mentioned it is by a significant margin more visual than mushrooms, so, very very pretty.

      The other major reason is to be able to tweak the receptors we want while also being able to pass a spontaneous drug test. Can get a pretty close equivalent to any illegal drug you like but it will be much cheaper and more than likely invisible to drug screenings. And legal to possess! I was pulled over with over 30 grams of 4-FA once. I spent an hour or two with those friendly police but they did give it back and let me go. It wasn’t even stored particularly classy — a quart sized ziploc with freehand huge brownish red “4-FA” scribbled on the side with a sharpie. Hah.

      And almost without exception an RC drug is vastly cheaper per dose than the similar effect street drug. We’re not all so rich and wanting to risk arrest. And with age it gets harder to source these things. I agree with the article writer. Let another RC golden age come! We should be able to pick and choose the aspects of whatever drugs we like and design a chemical that causes ONLY those things. Or has a different mixture o effects. Customize your psychedelic experience however you wish. Design out any negative or undesired aspects like nausea, or just make a recreational drug you like last half or twice as long with a single dose. All is possible exploring the many analogues!

      Blast wish I knew how to synthesize stuff myself!! Pikhal and Tikhal are super awesome reads and I also recommend checking them out for anyone who wants to grasp the scene and all its glorious possibilities a bit better. It’s about time for someone to write a similar book about analogue dissociatives (NMDA antagonists) and cannibinoids. Empathogens and stimulants and sedatives too I guess!

      If anyone has heard or can link some report showing proof of any tryptamine being particularly risky to ingest I would like to see it. They all seem to cause no lasting physical changes or risky death causing overdoses.

      Tread with caution when exploring opiate, dissociative, stimulant, sedative, or cannibinoid RCs, though. Their easy availability, cheap price, and low risk to possess make it quite easy to find yourself addicted or taking more than you would wish. And many RCs in these fields HAVE shown to have potential negative effects on ones health. Many in all those fields have also not shown any detrimental change at all from regular use. So we very well could find much safer drugs that do all the things the old tried and true illegal recreational drugs do. Sounds worth a little exploring to me to find safer versions of the drugs we already have and abuse so future generations are able to enjoy and indulge without having to worry as much about negative consequences. Find them suitable substitutes for cocaine or alcohol or heroin/prescription painkillers or stimulants or empathogens that are harder to overdose on, cause less physical side effects both short and long term, are harder to become addicted to, or much faster and less painful to withdraw from. But have no illusion, we will encounter many dangerous RCs in this pursuit, but we will also find safe ones. Poor horror stories from people who got addicted to U-44770! So caustic it has totally ruined peoples veins, anuses, and sinuses. Removed the ability of some people to smell FOREVER. Discolored and collapsed veins! Even just trying to eat some caused a huge sensitive scalding spot on my tongue that lasted a whole week, despite the fact it was only in contact for less than a second.

      But RCs still seem like a worthy venture for the human race to pursue, however slowly and independently. I am perfectly okay with letting the occasional person (like myself) knowingly choose and volunteer to test and face the risk of these drugs until we can determine which are dangerous and which are not. Some will hurt themselves through use of RCs, but really only a very small fraction of those who use them will cause any significant noticeable damage. 5%? Less? I don’t know. I’d be very surprised if it were over 10% though. I know quite a lot of people who have used RCs and I don’t know any personally who have caused permanent damage or impairment.

  4. The problem that you don’t mention is, of course, that almost all the drugs you mention are either extremely hard to make; unstable; or neurotoxic.

    Substituted cathinones are famous for being a “designer drug” class which has not only been a cancer to real MDMA or speed (it’s used to fake these, as it’s cheaper to make), but also causes hundreds of deaths each year. Cathinones are fundamentally dangerous for their tendancy to cause seizures, strokes, and psychotic episodes. They are also well-known for triggering nausea, Prinzmetal’s angina, and paranoid feelings; this being one of the reasons why dance floors around the world are a lot less “huggy” than they once were.

    This even occurs with the “base” compound from the plant cathis edula, where we see countries where it’s chewed have higher baseline rates of psychosis than neighboring countries where it’s not chewed.

    All the NBomE class drugs are neurotoxic.

    Methoxetamine produces cerebellar toxicity.

    PMA… well, that just flat out kills you via seratonin syndrome.

    The point here is that NO DRUG that has been invented over the last few decades has turned out to be safe and practical. However, foisting them on unsuspecting consumers by selling them as fakes HAS generated many thousands of deaths, killed the dance scene, and spawned an industry of reagent test kits.

    Good fuckin’ job, losers.

    • the dance floor, yeah !

    • 0 It’s actually very impressive that our knuckle dragging neanderthal friend John Smith could ( presumably over the time span of a few months) string together a criticism of the evolution of the drug market. That you have some basic understanding OF THE interactions between biological functions and drugs ( please don’t forget to cite Wikipedia). You have no understanding on how markets work, there will always be baptists and bootleggers we are IN Fact improving upon the determinants of their predecessors. Thatch how progress works we recognize the problem and then attempt to fix it. Tim Walker is a geocentric pseudo-intellectual; and the ideology that he is promoting causes deaths AND the spread of misinformation BECAUSE BOOTLEGGERS Capitalize on ignorance.

    • I go to raves at least once a month, the dance scene is fine lol

    • *gasp*! There are some humans on the planet who will do unscrupulous things to make money?? Even if it endangers others? I never would have guessed. I’m afraid this is an aspect of human experience we will not be able to shake off any time in the near future even if we stopped all RC research. Giving up now leaves us in your so well described situation, where people don’t know what they’re buying. With a few more decades of exploration I truly believe this will and should change to the benefit of all.

      As far as NO safe chemicals invented in past decades… I still have never heard of a particularly nasty long term effect from an RC tryptamine. And likewise, I don’t know the exact year it was synthesized but it is still considered an RC in the US at least — etizolam has been shown safer than all the common prescription benzodiazepines in multiple scientific tests investigating different effects. risks, and changes in body tissue or neurotransmitter balance or any such things. It is a prescription drug in some other advanced countries but I rather like the US not being one of those. Safer in multiple ways and not a single test has shown it to be more harmful, dangerous, risky, or damaging. Yet can still do all the medical benefits we desire and use the benzos for. Granted I did this research probably year or two ago so some new studies may be released by now. But there’s just something about tryptamines that never make me particularly concerned to try one. Most of the simple close to familiar tryptamine analogues anyway.

  5. its soo nice

  6. LOL “Geocentrism” is the next major taboo white liberals must carefully avoid and cower at.
    The writer of this article is an intrepid psychonaut advocating balls to the wall experimentation. However, the major concern is that because of the illegality of these substances (ever hear of the Analogue Act, folks? That’s the law that says if a prosecutor can make a slide show presentation that makes one drug look like another your goose is cooked)fraud will be a major issue. I’m sure I’m preaching to the choir here but how many more times is PMA going to be sold as MDMA? We need to change the laws NOW.

  7. Need reputable rc dealer for east coast USA plz lining for 5apb meohdrone 4fa rt1 series mt45 etc

  8. we do research chemicals

  9. I have been part of the RC scene for years now and have tried pretty much all the RC’s that have been and gone. I believe that the psychedelics, Cannabinoids and possibly the entactogens (simply because they allow a higher dosing of cannabinoids) allow for a unbelievable trip if dosed correctly! I used to find 70mg of AMT or 240 mg of 5/6apb in split doses including Noids can bring about a unique psychedelic experience. This is possibly because of antagonism of the 5HT2 receptor!! Its a shame the law gets in the way of true psychonaughts!!

  10. Looking for a legit cheap benzo rc dealer in USA or one that will ship to USA thanks

  11. I’m in need of a RC supplier for UK, from UK, for the next day deliveries. The PSA Ban soon to hit Germany in couple of weeks is a fucker. Neruotoxicity is a major factor, I couldn’t take MDMA everyday, Maybe Amphetamine, but I’ve been happy with 2 popular rchems MPA and 3FPM that can be taken daily whichever your prefered method ROA works with both, without the nasty withdrawals.

  12. Need A Fentynyl Or Other Opiate Rc Source PLease Thank you

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