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MXE: The Wonder Drug

The term “wonder drug”‘s definition is; “a drug, usually recently discovered or developed, noted for its startling curative effect, as an antibiotic or sulfa drug”. This definition usually would lead one to think that the World Health Organisation’s Essential Drug List would be made up solely of wonder drugs. This is, however, invariably wrong. Some of them may be classified as wonder drugs, of course. The problem is though, there are a lot of drugs in there that have been surpassed in recent years by a large divide. The other problem is that until a complete testing procedure has been passed, for the drug’s efficacy and safety profile, it cannot be entered into the list due to FDA approval. This process usually takes from five to ten years. The fact that our knowledge of pharmacology is increasing at an exponential rate, means that by the time the FDA has approved a certain compound it will already have been rendered obsolete.

This is almost paradoxical. We are increasing our knowledge incredibly quickly yet bureaucracy and medical authorities are far too slow to allow these novel compounds to exist in a legal setting. Therefore novel wonder drugs are sat in the grey zone. This means that they are available but only for research settings, and without the FDA’s approval they cannot be sold by pharmaceutical companies, making them cheap and easily available for those who know pharmacology and the research conducted in the process for FDA approval.

MXE, sadly, has been banned and as such it will not be going through this process. Ketamine, a close relative, is on the WHO essential drug list. However not for the purpose it should be intended for. The arylcyclohexylamine group is comprised of NMDA antagonists and opioids, and that perfect mixture of analgesia and serotonergic and dopaminergic activity makes them prime candidates for antidepressants without the heavy addiction that usually follows opioids, unless the compound in question has selective opioid activity such as Bromadol or 3-HO-PCP.

Other illegal compounds that could be classed as wonder drugs are psychedelics and empathogens such as Psilocin and MDMA. The fact that they are illegal does not prohibit them from having the potential to be a wonder drugs, it only prohibits the use of them. This is a major boon to psychotherapists and the health industry in general. The fact that these compounds can be abused is the reason to completely outlaw them, yet other much more destructive drugs that offer little insight in a psychotherapeutic setting such as opioids or stimulants are available through prescription, and essentially legal from a wider viewpoint.

The irony is almost too much to be taken seriously. As such it makes both the FDA and pharmaceutical companies look like “legal” heroin dealers, especially in countries where heroin (or Diamorphine) is available by prescription. The same goes for Cocaine, Amphetamines and Benzodiazepines, all very addictive and fairly ineffective compared to recent wonder drugs. For instance, in place of Cocaine, one could use similar, non-addictive local anaesthetics with no abuse potential, Amphetamines could be replaced by Orexin agonists, or wakefulness enhancers such as Modafinil (dopamine reuptake inhibitors with little abuse potential) and benzodiazepines with non-addictive anxiolytics (of which there are far too many to count). In the case of opioids, there are certain compounds which remove the addictive aspects of opioids, such as Enkephalinase Inhibitors, however these are still not acknowledged by the pharmaceutical society and why would they be? If you introduce a compound to make opioids safe, then sales would plummet. The same goes for cures for cancer and other life threatening diseases, of which there are many efficient compounds to plug the hole but are still not approved.

Back to MXE though, it is a wonder drug. It’s an almost perfect antidepressant, anxiolytic, neurogenerative compound with very few side effects and almost everyone that have used MXE for therapeutic purposes would explain how it is by far the most effective compound for a variety of mental disorders. It was discovered fairly recently and it entered the RC (research chemical) scene, where it proved to be incredibly popular and those with knowledge of it’s prowess, have benefited greatly from it, including myself.

The RC scene is on the cusp of recreational drug research and until recently, it was allowed to be conducted without harassment by laws and their enforcement. If such a compound was discovered through the first wave of recreational drug evolution, who knows what else could be out there with great health benefits, but under the blanket ban enforced by the UK (and soon the EU), the RC scene has gone quiet. It will be difficult to recover from such a state and as such our pharmacological knowledge has been stunted. Another factor prohibiting the expansion of psycho-pharmacology is the DNM (Dark Net Market) scene, where illegal compounds are sold widely. Before such places existed, the RC scene thrived and was the primary area of sale of drugs on the internet. They were all grey so sites could exist where they could be sold under the guise of the “not for human consumption” banner.

Since the revolutionary birth of DNMs however the RC scene has dwindled, the research began to focus on potent stimulants and cannabinoids and the growth of psychotherapeutic drugs such as psychedelic and dissociative drugs regressed into the state where only a few select (and old) compounds could be acquired. The research stood still. Nothing new was unveiled except for perhaps Diphenidine and other such compounds which are far too unpredictable to be used in a therapeutic setting. The recent blanket ban, however will destroy even these compounds though and we are soon to enter the dark ages for psychoactive research chemicals, while illegal drugs will continue to prosper on DNMs.

Creativity and novelty will slowly die and thus the evolution of pharmacology will die with it. Of course Big Pharma will continue to produce novel compounds but they would be subject to FDA approval and the process will be very slow in relation to the growth we’ve seen in the past few years.

‘How does one fix this?’, you may ask. The answer is simple. Open your mind, do not be afraid of novelty, become enthused with the fact that compounds that surpass every drug known today are out there, yet undiscovered and put faith in those who are trying to bring back the golden age of RCs. Instead of Heroin, buy Furanyl-Fentanyl, instead of LSD, get some ETH-LAD, instead of mushrooms, 4-HO-MiPT, instead of Xanax, get Clonazolam, instead of Cannabis, try out a cannabinoid reuptake inhibitor such as URB-597 or a non-selective cannabinoid such as JWH-073 and instead of Ketamine, get MXE.

A more optimal solution still, would be to enquire about novel compounds in these areas such as 5-TOET or 3a-Methyl-MDA (both a psychedelic and empathogen) as a psychedelic, bk-aMT as an empathogen, RB-101 and it’s relatives for removal of addiction to opioids, Levorphacetyl for the opioid to join it, Nitetrazepam as a benzo, cis-N-HO-4-MAR as a stimulant and MXPy (Methoxrolidine) instead of MXE. Together, as a social movement we could continue the introduction of novel compounds to the world and in time we will almost certainly find other wonder drugs and evolve psycho-pharmacology with the emphasis placed squarely upon what we do not know instead of what we do know.



  1. Where is the evidence that “MXE it’s an almost perfect antidepressant, anxiolytic, neurogenerative compound with very few side effects”?
    User´s experiences can not be used as a proof of safety or efficacy. There are no clinical trials on humans and risks are unknown. Ketamine has been used in humans for more than 50 years and we have enough knowledge about it. Ketamine has proven to be effective for some depressive disorders (but only in the short term, there are no long-time studies). Ketamine can cause addictive disorders and it is also related to bladder problems in intensive users.
    But this is not the case for MXE. The fact that it is structurally similar to ketamine does not mean that it has the same effects and risks. According to current scientific knowledge, MXE should be considered as a experimental compound of unknown effects and risks.

  2. Great article. Another fun fact about MXE (and ketamine) is that there is strong evidence that they can completely eliminate opiate withdrawal WITHOUT prolonging it

    • sickouz

      when i was in WD ketamine was the only thing that helped other than opiates themself, it doesnt rid the WD but you won’t give af about it anymore, it helps alot when one needs it

  3. Doctor X i havent seen you since the days of evo, come to the bay(alphabay) youll like it. but wise words for dr x and for the fact you said ont buy cannabis buy some other bs i never heard before threw me way tf off why would you even group cannabinoalds with LSD and and all those other drugs cannabis is def not in this class of drugs i woulndt even consider it that type of “drug” every drug grey are wonder drug you listed is a man made drug vs cannabis which clearly is a plant no diffrent than the millions of other plabts found around the planet man made vs natural are on two entrily diffrent sides. your no diffrent that the big pharm comapines trying to paint weed as a fucking drug its a god damn plant it was a plant before human cilivalzion and it will be a planet after humean civilaztion smh

    Sorry for spelling

    • Allison Reagan

      Drug users write funny, all excited-like.

    • Jellybean

      Opium is from a plant, cocaine is from a plant so are these perfectly safe too seeing as they’re all plants?
      I’m an addict from over 25 years and have gotten clean twice in the past, both times I said weed is OK its not like the other drugs and both times I didn’t stay off anything very long. I don’t consider weed very harmful but I can’t say its harmless, anyone that does isn’t aware of all the facts.

      • lex luthor

        lol its funny how ppl always take their favorite drug and romantasize the shit out of it and call it natural and healthy and hell I am expecting someone to pitch in here how weed cures all cancer all the time(funny cuz all those ppl smoking pot ILLEGALLY for chemo nausea for decades b4 medical mj began to be legalized all still Fing died from cancer, I guess you have to know that weed cures cancer for it to actually work huh? or i guess the weed they were smoking was the super magic weed that cures all cancer that seems to be mentioned in half the pro legalization pot memes out there). At this point how much credit pot gets for how little proof is shown for it to deserve said credit, it just sounds like propaganda with “some” ppl who def enjoy pot willing to say just about anything if they think it helps their cause. To me that just confounding, I like pot and pot is good enough on its own without needing to lie about it and imbue it with characteristics that exist more in your head that in the real world.

        I am never sure what to think when someone tries to pretend their shit doesn’t stink all while providing absolutely no evidence to back anything they say up. Outside of some obvious observations that like crack and alcohol have heavier social consequences for sure, but to quantify that medically is hard, and not to mention not done enough times to have solid enough research for ppl to spout off absolute statements on how something is or isn’t harmful to someones health. As someone else mentioned cocaine and morphine are just as naturally occuring as THC. Why is thc the only natural drug again and apperantly the only safe one because of this “naturalness?” where did this gem come from? In fact they are nothing less natural than what butane hash oil extract is compared to pot. We just figured out how to concentrate them long before we did so efficiently with weed, or maybe not figured out but chose to proceed with and trying to make a buck off in the medicinal world. But I digress… if you think something being natural makes it ok, I hate to break it to ya, but arsenic occurs naturally in the world. So plz stop emberassing yourself with this “the drugs I do don’t count as drugs cuz they grow in the ground naturally” nonsense… as non prude open minded person i think anything is harmless if you simply stay in control and don’t use often… and you sir sound word for word like every alcoholic that has ever tried to talk down to me about how me taking an e pill every 2 months is deprived debauchery, and when I point to the beer in their hand they literally say just like you “oh dude this doesn’t count, oh I have a beer after every meal its food not drugs, its not a drug the way I USE it, it DOESN’T COUNT” and blah blah blah more dumb shit like that, that is nothing more than self serving drivel… so plz… don’t be like that guy. I love pot, I just smoked some, but I don’t have to lie to myself that its not a drug in order to be ok with it. Mmmkay

    • Spizzle

      Cannabis is definitely psychedelic. It therefore has something in common with LSD. No one will take you seriously when you write with such contempt for English. How about an effing spell checker you yob.

  4. Hi,

    Whoever posted this article, you mention many better alternatives for anxiolytics beside benzodiazepines, what are they?

  5. beware of mxe

  6. You sir, the OP, are an imbecile. There have been numerous deaths via RC drug use. People who migh have otherwise taken a much safer dose of MDMA instead chose a potent, untested analogue & or cathinone that resulted in death. The same has occured with psychadelic RC’s. Deaths have occured due to the vastly different toxic dose range of 25i as compared to the much safer and studied drugs such as LSD, Psilocybin and Mescaline.
    Some people may be concerned about drug tests so they turn to potentially dangerous RCs rather than drugs that have been tested with a known / verified therapeutic dose range, recreational range and potentially fatal range.

  7. Of course the DEA guidlines are flawed and there is bureaucratic bulllshit regarding pharmaceutical research, patents, special interest campaign financing, etc., etc., etc. An example would be Hydrocodone being schedule 3 if it is mixed with liver toxic Tylenol but schedule 2 if it is pure Hydrocodone. Gee that one really makes sense. But testing guidelines requiring research trials to approve a drug are far better than some – idiot like the OP risking death by taking an unknown safe dose range of a new, untested analogue RC.

    All of your claims about wonderous replacements for cocaine, tranqualizers, opiates and cannabis are 100 % unfounded with 0% research to back up your claims. The so called research behind RCs comes down to the OP being a Guinnea pig in uncontrolled experiments.

    The more logical option is to decriminalize drugs and offer unbiased public harm reduction info on the less dangerous use of drugs

  8. “there is strong evidence that they can completely eliminate opiate withdrawal WITHOUT prolonging it”

    any data to support this sentence?

  9. This article reads as if it was written by some full-of-shit RC peddler .

  10. allegedly a dependable drug for all kinds of addiction. It’s a drug called ibogain. It’s about finding a lot of information.

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